Analysis of global transcriptional responses of chicken following primary and secondary Eimeria acervulina infections.

ABSTRACT:

Background

Characterization of host transcriptional responses during coccidia infections can provide new clues for the development of alternative disease control strategies against these complex protozoan pathogens.

Methods

In the current study, we compared chicken duodenal transcriptome profiles following primary and secondary infections with Eimeria acervulina using a 9.6K avian intestinal intraepithelial lymphocyte cDNA microarray (AVIELA).

Results

Gene Ontology analysis showed that primary infection significantly modulated the levels of mRNAs for genes involved in the metabolism of lipids and carbohydrates as well as those for innate immune-related genes. By contrast, secondary infection increased the levels of transcripts encoded by genes related to humoral immun

SUBMITTER: Kim CH 

PROVIDER: S-EPMC3108206 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature