Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis.

ABSTRACT:

Background

When the case-only study design is used to estimate statistical interaction between genetic (G) and environmental (E) exposures, G and E must be independent in the underlying population, or the case-only estimate of interaction (COR) will be biased. Few studies have examined the occurrence of G-E association in published control group data.

Methods

To examine the assumption of G-E independence in empirical data, we conducted a systematic review and meta-analysis of G-E associations in controls for frequently investigated DNA repair genes (XRCC1 Arg399Gln, Arg194Trp, or Arg280His, XPD Lys751Gln, and Asp312Asn, and XRCC3 Thr241Met), and smoking (ever/never smoking, current/not current smoker, smoking duration, smoking intensity, and pack-years).

Results

Acros

SUBMITTER: Hodgson ME 

PROVIDER: S-EPMC3108462 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature