A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.

ABSTRACT: Neurodegenerative diseases, such as multiple sclerosis represent global health issues. Accordingly, there is an urgent need to understand the pathogenesis of this and other central nervous system disorders, so that more effective therapeutics can be developed. Cerebrospinal fluid is a potential source of important reporter molecules released from various cell types as a result of central nervous system pathology. Here, we report the development of an unbiased approach for the detection of reactive cerebrospinal fluid molecules and target brain proteins from patients with multiple sclerosis. To help identify molecules that may serve as clinical biomarkers for multiple sclerosis, we have biotinylated proteins present in the cerebrospinal fluid and tested their reactivity against brain homoge

SUBMITTER: Menon KN 

PROVIDER: S-EPMC3108827 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature