Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma.

ABSTRACT:

Purpose

To analyze two candidate genes, trabecular meshwork inducible glucocorticoid response (MYOC/TIGR) and human dioxin-inducible cytochrome P450 (CYP1B1), in a Chinese pedigree of primary open-angle glaucoma.

Methods

In a three-generation family containing 14 members, four of them were patients with primary open-angle glaucoma, one was a glaucoma suspect, and the rest were asymptomatic. All members of the family underwent complete ophthalmologic examinations. Exons of MYOC and CYP1B1 were amplified by polymerase chain reaction, sequenced, and compared with a reference database.

Results

Elevated intraocular pressure and impaired visual field were found in all patients. One MYOC heterozygous mutation G367R, in exon 3 was identified in four patients and the suspect,

SUBMITTER: Chen J 

PROVIDER: S-EPMC3108900 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature