Rule-guided executive control of response inhibition: functional topography of the inferior frontal cortex.

ABSTRACT:

Background

The human inferior frontal cortex (IFC) is a large heterogeneous structure with distinct cytoarchitectonic subdivisions and fiber connections. It has been found involved in a wide range of executive control processes from target detection, rule retrieval to response control. Since these processes are often being studied separately, the functional organization of executive control processes within the IFC remains unclear.

Methodology/principal findings

We conducted an fMRI study to examine the activities of the subdivisions of IFC during the presentation of a task cue (rule retrieval) and during the performance of a stop-signal task (requiring response generation and inhibition) in comparison to a not-stop task (requiring response generation but not inhibition). We

SUBMITTER: Cai W 

PROVIDER: S-EPMC3108978 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature