Regulation of ocular angiogenesis by Notch signaling: implications in neovascular age-related macular degeneration.

ABSTRACT:

Purpose

Wet age-related macular degeneration (AMD), which accounts for most AMD-related vision loss, is characterized by choroidal neovascularization (CNV). The underlying mechanism of CNV is poorly understood, but evidence indicates pathologic recruitment of normal angiogenic signaling pathways such as the VEGF pathway. Recent evidence suggests that the VEGF pathway regulates angiogenesis in concert with Notch signaling. Here, the authors examined the role of Notch signaling in CNV in the backdrop of Notch signaling-mediated regulation of retinal angiogenesis.

Methods

Choroid sclera complexes, after laser-induced CNV, were examined for changes in CNV lesion volume and in proangiogenic and antiangiogenic gene expression after perturbation in Notch signaling. Retinal vessels

SUBMITTER: Ahmad I 

PROVIDER: S-EPMC3109005 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature