Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes.

ABSTRACT:

Purpose

The recent FIELD study demonstrated that the lipid-lowering agent fenofibrate significantly reduces the development and progression of diabetic retinopathy (DR). These results suggest that lipids may play a causal role in DR. They also suggest that AMP-activated protein kinase (AMPK) activation could account for these findings given that fenofibrate is an AMPK activator. The authors previously demonstrated that free fatty acids, in addition to hyperglycemia, can induce apoptosis in retinal pericytes (PCs), the first cells lost in the diabetic retina. Incubation with the saturated fatty acid palmitate, but not the monounsaturated fatty acid oleate, elicited cytotoxicity in a manner dependent on oxidative stress, NF-κB activation, and ceramide accumulation. In this study, the

SUBMITTER: Cacicedo JM 

PROVIDER: S-EPMC3109045 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature