Weighting components of composite end points in clinical trials: an approach using disability-adjusted life-years.

ABSTRACT:

Background and purpose

Conventional analysis of vascular prevention trials assigns equal weight to disparate vascular events in a composite end point at variance with the public's perception of their differential impact on health outcome. This study sought to apply the disability-adjusted life-year (DALY) metric to differential weighting individual vascular end points in trial analyses.

Methods

DALY values for the most common major end points in vascular prevention trials (nonfatal myocardial infarction, nonfatal stroke, and vascular death), were derived by using World Health Organization Global Burden of Disease Project methodology. The standardized DALYs for each event were applied to recent major primary and secondary vascular prevention trials and to hypothetical model t

SUBMITTER: Hong KS 

PROVIDER: S-EPMC3109505 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature