An embryonic stage-specific enhancer within the murine β-globin locus mediates domain-wide histone hyperacetylation.

ABSTRACT: In mammalian nuclei, a select number of tissue-specific gene loci exhibit broadly distributed patterns of histone modifications, such as histone hyperacetylation, that are normally associated with active gene promoters. Previously, we characterized such hyperacetylated domains within mammalian β-globin gene loci, and determined that within the murine locus, neither the β-globin locus control region nor the gene promoters were required for domain formation. Here, we identify a developmentally specific erythroid enhancer, hypersensitive site-embryonic 1 (HS-E1), located within the embryonic β-globin domain in mouse, which is homologous to a region located downstream of the human embryonic ε-globin gene. This sequence exhibits nuclease hypersensitivity in primitive erythroid cells and acts as

SUBMITTER: Fromm G 

PROVIDER: S-EPMC3109543 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature