Aza-Nazarov cyclization cascades.

ABSTRACT: Benzamides with tethered acetal groups undergo reactions in CF(3)SO(3)H to give ring-fused isoindolinones by a cyclization cascade. The reaction initially forms an N-acyliminium ion which then gives the isoindolinone by the aza-Nazarov reaction. An unusual variant also cyclizes at the allylic position.

SUBMITTER: Sai KK 

PROVIDER: S-EPMC3109674 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature