Ontology highlight
ABSTRACT:
SUBMITTER: Herold JM
PROVIDER: S-EPMC3109722 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110318 7
Proteins which bind methylated lysines ("readers" of the histone code) are important components in the epigenetic regulation of gene expression and can also modulate other proteins that contain methyl-lysine such as p53 and Rb. Recognition of methyl-lysine marks by MBT domains leads to compaction of chromatin and a repressed transcriptional state. Antagonists of MBT domains would serve as probes to interrogate the functional role of these proteins and initiate the chemical biology of methyl-lysi ...[more]