Ontology highlight
ABSTRACT:
SUBMITTER: Linger R
PROVIDER: S-EPMC3109865 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Genes, chromosomes & cancer 20080301 3
A base substitution in the mouse Dnd1 gene resulting in a truncated Dnd protein has been shown to be responsible for germ cell loss and the development of testicular germ cell tumors (TGCT) in the 129 strain of mice. We investigated the human orthologue of this gene in 263 patients (165 with a family history of TGCT and 98 without) and found a rare heterozygous variant, p. Glu86Ala, in a single case. This variant was not present in control chromosomes (0/4,132). Analysis of the variant in an add ...[more]