Common viruses associated with lower pediatric multiple sclerosis risk.

ABSTRACT:

Background

Because common viruses are encountered during childhood, pediatric multiple sclerosis (MS) offers a unique opportunity to investigate the influence of these viruses on disease susceptibility and the interactions between seroprevalence and select HLA genotypes. We studied seroprevalence for Epstein-Barr virus (EBV), cytomegalovirus (CMV), and herpes simplex virus (HSV) type 1 and HLA-DRB1*1501/1503 status as predictors of pediatric MS.

Methods

This was a retrospective analysis of prospectively collected demographic, clinical, and biologic data in subjects up to 18 years of age with early MS, control subjects seen at the same regional referral pediatric MS clinics, and additional healthy pediatric control subjects.

Results

Patients with early pediatric MS (n=

SUBMITTER: Waubant E 

PROVIDER: S-EPMC3109881 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature