Beta Blockade after myocardial infarction: systematic review and meta regression analysis.

ABSTRACT:

Objectives

To assess the effectiveness of beta blockers in short term treatment for acute myocardial infarction and in longer term secondary prevention; to examine predictive factors that may influence outcome and therefore choice of drug; and to examine the clinical importance of the results in the light of current treatment.

Design

Systematic review of randomised controlled trials.

Setting

Randomised controlled trials.

Subjects

Patients with acute or past myocardial infarction.

Intervention

beta Blockers compared with control.

Main outcome measures

All cause mortality and non-fatal reinfarction.

Results

Overall, 5477 of 54 234 patients (10.1%) randomised to beta blockers or control died. We identified a 23% reduction in the odds of death

SUBMITTER: Freemantle N 

PROVIDER: S-EPMC31101 | biostudies-literature | 1999 Jun

REPOSITORIES: biostudies-literature