Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.

ABSTRACT: Identification of early mechanisms that may lead from obesity towards complications such as metabolic syndrome is of great interest. Here we performed lipidomic analyses of adipose tissue in twin pairs discordant for obesity but still metabolically compensated. In parallel we studied more evolved states of obesity by investigating a separated set of individuals considered to be morbidly obese. Despite lower dietary polyunsaturated fatty acid intake, the obese twin individuals had increased proportions of palmitoleic and arachidonic acids in their adipose tissue, including increased levels of ethanolamine plasmalogens containing arachidonic acid. Information gathered from these experimental groups was used for molecular dynamics simulations of lipid bilayers combined with dependency network

SUBMITTER: Pietilainen KH 

PROVIDER: S-EPMC3110175 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature