MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R.

ABSTRACT:

Background

Psoriasis is a complex disease at the cellular, genomic and genetic levels. The role of microRNAs in skin development was shown in a keratinocyte-specific Dicer knockout mouse model. Considering that two main characteristics of psoriasis are keratinocytes hyperproliferation and abnormal skin differentiation, we hypothesized that aberrant microRNA expression contributes to the psoriatic phenotype. Here, we describe the differential expression of miRNAs in psoriatic involved and uninvolved skin as compared to normal skin, revealing an additional aspect of this complex disorder.

Methodology/principal findings

Expression arrays were used to compare microRNA expression in normal skin versus psoriatic involved and uninvolved skin. Fourteen differentially expressed micro

SUBMITTER: Lerman G 

PROVIDER: S-EPMC3110257 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature