Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma.

ABSTRACT: We present the design features and implementation of a clinic-based case-control study on the molecular epidemiology of lymphoma conducted at the Mayo Clinic (Rochester, Minnesota, USA), and then assess the internal and external validity of the study. Cases were newly diagnosed lymphoma patients from Minnesota, Iowa and Wisconsin seen at Mayo and controls were patients from the same region without lymphoma who had a pre-scheduled general medical examination, frequency matched on age, sex and residence. Overall response rates were 67% for cases and 70% for controls; response rates were lower for cases and controls over age 70 years, cases with more aggressive disease, and controls from the local area, although absolute differences were modest. Cases and controls were well-balanced on age, s

SUBMITTER: Cerhan JR 

PROVIDER: S-EPMC3110384 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature