Superelectrophilic chemistry of amino-nitriles and related substrates.

ABSTRACT: The superacid-promoted Houben-Hoesch reactions of amino-nitriles and related compounds have been studied. The nitriles form dicationic electrophiles and react with benzene in fair to good yields (12-95%). The intermediate iminium ions may also be reduced to the benzylic amines by NaBH(4) or H(2).

SUBMITTER: Raja EK 

PROVIDER: S-EPMC3110710 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature