Design and Synthesis of a Fluorescently End-Labeled Poly(β-amino ester): Application to the Characterization of Degradable Polyelectrolyte Multilayers.

ABSTRACT: We report the synthesis of a fluorescently end-labeled analog of a synthetic and degradable cationic poly(β-amino ester) (PBAE; polymer 1) used in past studies for the delivery of DNA and the layer-by-layer assembly of erodible polyelectrolyte multilayers (PEMs). The synthesis of an analog of polymer 1 having acrylate functionalized end groups provided a platform for the introduction of fluorescent labels by post-polymerization conjugate addition of amine-functionalized fluorophores. This approach enabled the synthesis of fluorescently end-labeled polymer (polymer 1(FL)) with molecular weights and polydispersities (M(n) = 18,000; PDI ~1.8) similar to those used in past studies for the fabrication of PEMs using polymer 1. Layer-by-layer assembly of PEMs using polymer 1(FL) and poly(styrene

SUBMITTER: Bechler SL 

PROVIDER: S-EPMC3110734 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature