Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial.

ABSTRACT:

Background

the effects of smoking and smoking cessation on lipoproteins have not been studied in a large contemporary group of smokers. This study was designed to determine the effects of smoking cessation on lipoproteins.

Methods

this was a 1-year, prospective, double-blind, randomized, placebo-controlled clinical trial of the effects of 5 smoking cessation pharmacotherapies. Fasting nuclear magnetic resonance spectroscopy lipoprotein profiles were obtained before and 1 year after the target smoking cessation date. The effects of smoking cessation and predictors of changes in lipoproteins after 1 year were identified by multivariable regression.

Results

the 1,504 current smokers were (mean [SD]) 45.4 (11.3) years old and smoked 21.4 (8.9) cigarettes per day at baseli

SUBMITTER: Gepner AD 

PROVIDER: S-EPMC3110741 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature