Ontology highlight
ABSTRACT:
SUBMITTER: Shin S
PROVIDER: S-EPMC3110956 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Genes & development 20110601 11
Isolation of hepatic progenitor cells is a promising approach for cell replacement therapy of chronic liver disease. The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice with a 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet led to an increase of the perc ...[more]