Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response.

ABSTRACT: Current studies of particulate matter (PM) are confounded by the fact that PM is a complex mixture of primary (crustal material, soot, metals) and secondary (nitrates, sulfates, and organics formed in the atmosphere) compounds with considerable variance in composition by sources and location. We have developed a laboratory-based PM that is replicable, does not contain dust or metals and that can be used to study specific health effects of PM composition in animal models. We exposed both neonatal (7 days of age) and adult rats to a single 6-h exposure of laboratory generated fine diffusion flame particles (DFP; 170 µg/m(3)), or filtered air. Pulmonary gene and protein expression as well as indicators of cytotoxicity were evaluated 24 h after exposure. Although DFP exposure did not alter air

SUBMITTER: Van Winkle LS 

PROVIDER: S-EPMC3111018 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature