Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

ABSTRACT:

Context

Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD).

Objective

To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach.

Design

Discovery-phase proteomics to identify plasma proteins associated with correlates of AD pathology. Confirmation and validation using immunodetection in a replication set and an animal model.

Setting

A multicenter European study (AddNeuroMed) and the Baltimore Longitudinal Study of Aging.

Participants

Patients with AD, subjects with mild cognitive impairment, and healthy controls with standardized clinical assessments and structural neuroimaging.

Main outcome measures

Association of plasma proteins with brain atrophy, diseas

SUBMITTER: Thambisetty M 

PROVIDER: S-EPMC3111021 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature