Divergence of function in sequence-related groups of Escherichia coli proteins.

ABSTRACT: The most prominent mechanism of molecular evolution is believed to have been duplication and divergence of genes. Proteins that belong to sequence-related groups in any one organism are candidates to have emerged from such a process and to share a common ancestor. Groups of proteins in Escherichia coli having sequence similarity are mostly composed of proteins with closely related function, but some groups comprise proteins with unrelated functions. In order to understand how function can change while sequences remain similar, we have examined some of these groups in detail. The enzymes analyzed in this work include representatives of amidotransferases, phosphotransferases, decarboxylases, and others. Most sequence-related groups contain enzymes that are in the same classes of Enzyme Commi

SUBMITTER: Nahum LA 

PROVIDER: S-EPMC311106 | biostudies-literature | 2001 Aug

REPOSITORIES: biostudies-literature