Upregulation of MAPK pathway is associated with survival in castrate-resistant prostate cancer.

ABSTRACT:

Background

Recent evidence has implicated the MAP kinase (MAPK) pathway with the development of castrate-resistant prostate cancer (CRPC). We have previously reported gene amplification of critical members of this pathway with the development of castrate-resistant disease. In addition, we have shown that rising Raf-1 expression, with the development of CRPC, influences time to biochemical relapse. We therefore sought to further analyse the role of both Raf-1 and its downstream target MAPK in the molecular pathogenesis of CRPC.

Methods

Protein expression of Raf-1 and MAPK, including their activation status, was analysed using immunohistochemistry in a database of 65 paired tumour specimens obtained before and after the development of CRPC and correlated with other members of

SUBMITTER: Mukherjee R 

PROVIDER: S-EPMC3111196 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature