Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.

ABSTRACT: Telomerases constitute a group of specialized ribonucleoprotein enzymes that remediate chromosomal shrinkage resulting from the "end-replication" problem. Defects in telomere length regulation are associated with several diseases as well as with aging and cancer. Despite significant progress in understanding the roles of telomerase, the complete structure of the human telomerase enzyme bound to telomeric DNA remains elusive, with the detailed molecular mechanism of telomere elongation still unknown. By application of computational methods for distant homology detection, comparative modeling, and molecular docking, guided by available experimental data, we have generated a three-dimensional structural model of a partial telomerase elongation complex composed of three essential protein domai

SUBMITTER: Steczkiewicz K 

PROVIDER: S-EPMC3111281 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature