Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.

ABSTRACT: Vertebrate genomes contain multiple copies of related genes that arose through gene duplication. In the past it has been proposed that these duplicated genes were retained because of acquisition of novel beneficial functions. A more recent model, the duplication-degeneration-complementation hypothesis (DDC), posits that the functions of a single gene may become separately allocated among the duplicated genes, rendering both duplicates essential. Thus far, empirical evidence for this model has been limited to the engrailed and sox family of developmental regulators, and it has been unclear whether it may also apply to ubiquitously expressed genes with essential functions for cell survival. Here we describe the cloning of three zebrafish alpha subunits of the Na(+),K(+)-ATPase and a comprehe

SUBMITTER: Serluca FC 

PROVIDER: S-EPMC311157 | biostudies-literature | 2001 Oct

REPOSITORIES: biostudies-literature