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Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.

ABSTRACT: A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.

SUBMITTER: Carr G 

PROVIDER: S-EPMC3111747 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.

Carr Gavin G   Seyedsayamdost Mohammad R MR   Chandler Josephine R JR   Greenberg E Peter EP   Clardy Jon J  

Organic letters 20110526 12

A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family. ...[more]

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