Inflammation-related gene variants as risk factors for pancreatic cancer.

ABSTRACT:

Background

Recent reports support an association between chronic inflammation and progression to pancreatic cancer (PC).

Methods

This case-control, candidate gene association study evaluated 1,354 Caucasian patients with pancreatic ductal adenocarcinoma and 1,189 healthy Caucasian controls. We genotyped 1,538 single nucleotide polymorphism (SNP) in 102 genes from inflammatory pathways involving NF-κB. Primary tests of association assumed a multiplicative (log-additive) genotype effect; secondary analyses examined dominant, additive, and recessive SNP effects.

Results

After adjusting for known risk factors for PC, single SNP analysis revealed an association between four SNPs in NOS1 and one in the CD101 gene with PC risk. These results, however, were not replicated in

SUBMITTER: Reid-Lombardo KM 

PROVIDER: S-EPMC3111756 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature