A novel high-throughput imaging system for automated analyses of avoidance behavior in zebrafish larvae.

ABSTRACT: Early brain development can be influenced by numerous genetic and environmental factors, with long-lasting effects on brain function and behavior. The identification of these factors is facilitated by recent innovations in high-throughput screening. However, large-scale screening in whole organisms remains challenging, in particular when studying changes in brain function or behavior in vertebrate model systems. In this study, we present a novel imaging system for high-throughput analyses of behavior in zebrafish larvae. The three-camera system can image 12 multiwell plates simultaneously and is unique in its ability to provide local visual stimuli in the wells of a multiwell plate. The acquired images are converted into a series of coordinates, which characterize the location and orientat

SUBMITTER: Pelkowski SD 

PROVIDER: S-EPMC3111907 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature