MG53 participates in ischaemic postconditioning through the RISK signalling pathway.

ABSTRACT:

Aims

Recent studies show that ischaemic postconditioning (PostC), similar to the well-established ischaemic preconditioning (IPC), confers cardioprotection against ischaemia/reperfusion (IR) injury, and both IPC and PostC can activate the reperfusion injury salvage kinase (RISK) pathway and the survivor activating factor enhancement (SAFE) pathway. PostC is clinically more attractive because of its therapeutic application at the predictable onset of reperfusion. Our previous studies have demonstrated that MG53 is a primary component of the IPC machinery. Here, we investigated the potential role of MG53 in PostC-mediated myocardial protection and explored the underlying mechanism.

Methods and results

Using Langendorff perfusion, we investigated IR injury in wild-type (wt) and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3112015 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature