Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation.

ABSTRACT:

Aims

Vascular peroxidase 1 (VPO1) is a newly identified haem-containing peroxidase that catalyses the oxidation of a variety of substrates by hydrogen peroxide (H(2)O(2)). Considering the well-defined effects of H(2)O(2) on the vascular remodelling during hypertension, and that VPO1 can utilize H(2)O(2) generated from co-expressed NADPH oxidases to catalyse peroxidative reactions, the aims of this study were to determine the potential role of VPO1 in vascular remodelling during hypertension.

Methods and results

The vascular morphology and the expression of VPO1 in arterial tissues of spontaneously hypertensive rats and Wistar-Kyoto rats were assessed. The VPO1 expression was significantly increased concomitantly with definite vascular remodelling assessed by evaluating the m

SUBMITTER: Shi R 

PROVIDER: S-EPMC3112017 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature