No association between polymorphisms/haplotypes of the vascular endothelial growth factor gene and preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is the first worldwide cause of death in pregnant women, intra-uterine growth retardation, and fetal prematurity. Some vascular endothelial grown factor gene (VEGF) polymorphisms have been associated to PE and other pregnancy disturbances. We evaluated the associations between VEGF genotypes/haplotypes and PE in Mexican women.

Methods

164 pregnant women were enrolled in a case-control study (78 cases and 86 normotensive pregnant controls). The rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (+405G/C), and rs25648 (-7C/T), VEGF variants were discriminated using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) methods or Taqman single nucleotide polymorphism (SNP) assays.

Results

The proportions of the min

SUBMITTER: Garza-Veloz I 

PROVIDER: S-EPMC3112063 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature