Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease.

ABSTRACT:

Background

Peroxisome proliferator-activated receptor-γ co-activator (PGC)-1α is a transcriptional co-activator of antioxidant genes and a master regulator of mitochondrial biogenesis. Parkinson's disease (PD) is associated with oxidative stress and mitochondrial dysfunction and recent work suggests a role for PGC-1α. We hypothesized that the rs8192678 PGC-1α single nucleotide polymorphism (SNP) may influence risk or age of onset of PD. The A10398G mitochondrial SNP has been inversely associated with risk of PD in some studies. In the current study we analyzed whether rs8192678 or other PGC-1α SNPs affect PD risk or age of onset, singularly or in association with the A10398G SNP.

Methods

Genomic DNA samples from 378 PD patients and 173 age-matched controls were analyzed by m

SUBMITTER: Clark J 

PROVIDER: S-EPMC3112073 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature