Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.

ABSTRACT:

Background

Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach in children's health research. The study incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease with etiology related to gene-environment interactions.

Methods/design

205 non-asthmatic and asthmatic children, (9-12 years of age) from Detroit, Michigan were recruited. The study includes environmental measures (indoor and outdoor air, vacuum dust), biomarkers of exposure (cotinine, metals, total and allergen specifi

SUBMITTER: Gallagher J 

PROVIDER: S-EPMC3112137 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature