Understanding and predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using domain genetic interactions.

ABSTRACT:

Background

Synthetic lethal genetic interactions among proteins have been widely used to define functional relationships between proteins and pathways. However, the molecular mechanism of synthetic lethal genetic interactions is still unclear.

Results

In this study, we demonstrated that yeast synthetic lethal genetic interactions can be explained by the genetic interactions between domains of those proteins. The domain genetic interactions rarely overlap with the domain physical interactions from iPfam database and provide a complementary view about domain relationships. Moreover, we found that domains in multidomain yeast proteins contribute to their genetic interactions differently. The domain genetic interactions help more precisely define the function related to the synt

SUBMITTER: Li B 

PROVIDER: S-EPMC3113237 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature