Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies.

ABSTRACT:

Background

Insulin-like growth factor 1 (IGF1) stimulates mitosis and inhibits apoptosis. Some published results have shown an association between circulating IGF1 and breast-cancer risk, but it has been unclear whether this relationship is consistent or whether it is modified by IGF binding protein 3 (IGFBP3), menopausal status, oestrogen receptor status or other factors. The relationship of IGF1 (and IGFBP3) with breast-cancer risk factors is also unclear. The Endogenous Hormones and Breast Cancer Collaborative Group was established to analyse pooled individual data from prospective studies to increase the precision of the estimated associations of endogenous hormones with breast-cancer risk.

Methods

Individual data on prediagnostic IGF1 and IGFBP3 concentrations were obta

SUBMITTER: Endogenous Hormones and Breast Cancer Collaborative Group 

PROVIDER: S-EPMC3113287 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature