Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum.

ABSTRACT:

Background

The cerebellum is composed of a diverse array of neuronal subtypes. Here we have used a candidate approach to identify Zac1, a tumor suppressor gene encoding a zinc finger transcription factor, as a new player in the transcriptional network required for the development of a specific subset of cerebellar nuclei and a population of Golgi cells in the cerebellar cortex.

Results

We found that Zac1 has a complex expression profile in the developing cerebellum, including in two proliferating progenitor populations; the cerebellar ventricular zone and the external granular layer overlying posterior cerebellar lobules IX and X. Zac1 is also expressed in some postmitotic cerebellar neurons, including a subset of GABAergic interneurons in the medial cerebellar nuclei. Notab

SUBMITTER: Chung SH 

PROVIDER: S-EPMC3113315 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature