Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene.

ABSTRACT:

Objective

To assess whether genetic variants involved in inflammation play a role in the sex difference in depression. Depression is, in part, genetically determined and inflammation has been implicated. Women are twice as likely to develop depression as men.

Methods

We examined the association, separately in men and women, between seven single nucleotide polymorphisms (SNPs) in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and 12 SNPs in the leukotriene A4 hydrolase (LTA4H) gene and depression in 1368 white subjects (30.4% female) referred for cardiovascular evaluation. Depression was defined as a score of >or=10 in the Patient Health Questionnaire 9. Single marker analysis was assessed by the chi(2) test. Haplotype-specific associations were performed,

SUBMITTER: Zhao J 

PROVIDER: S-EPMC3113512 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature