ArrayInitiative - a tool that simplifies creating custom Affymetrix CDFs.

ABSTRACT:

Background

Probes on a microarray represent a frozen view of a genome and are quickly outdated when new sequencing studies extend our knowledge, resulting in significant measurement error when analyzing any microarray experiment. There are several bioinformatics approaches to improve probe assignments, but without in-house programming expertise, standardizing these custom array specifications as a usable file (e.g. as Affymetrix CDFs) is difficult, owing mostly to the complexity of the specification file format. However, without correctly standardized files there is a significant barrier for testing competing analysis approaches since this file is one of the required inputs for many commonly used algorithms. The need to test combinations of probe assignments and analysis algorithms

SUBMITTER: Overall CC 

PROVIDER: S-EPMC3113937 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature