PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality.

ABSTRACT:

Background

The rational design of modified proteins with controlled stability is of extreme importance in a whole range of applications, notably in the biotechnological and environmental areas, where proteins are used for their catalytic or other functional activities. Future breakthroughs in medical research may also be expected from an improved understanding of the effect of naturally occurring disease-causing mutations on the molecular level.

Results

PoPMuSiC-2.1 is a web server that predicts the thermodynamic stability changes caused by single site mutations in proteins, using a linear combination of statistical potentials whose coefficients depend on the solvent accessibility of the mutated residue. PoPMuSiC presents good prediction performances (correlation coefficient

SUBMITTER: Dehouck Y 

PROVIDER: S-EPMC3113940 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature