GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models.

ABSTRACT:

Background

G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and physiological function. GPCR malfunction is responsible for a wide range of diseases including cancer, diabetes and hyperthyroidism and a large proportion of drugs on the market target these receptors. The three dimensional structure of GPCRs is important for elucidating the molecular mechanisms underlying these diseases and for performing structure-based drug design. Although structural data are restricted to only a handful of GPCRs, homology models can be used as a proxy for those receptors not having crystal structures. However, many researchers working on GPCRs are not experienced homology modellers and

SUBMITTER: Worth CL 

PROVIDER: S-EPMC3113946 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature