Structural characteristics and antiviral activity of multiple peptides derived from MDV glycoproteins B and H.

ABSTRACT:

Background

Marek's disease virus (MDV), which is widely considered to be a natural model of virus-induced lymphoma, has the potential to cause tremendous losses in the poultry industry. To investigate the structural basis of MDV membrane fusion and to identify new viral targets for inhibition, we examined the domains of the MDV glycoproteins gH and gB.

Results

Four peptides derived from the MDV glycoprotein gH (gHH1, gHH2, gHH3, and gHH5) and one peptide derived from gB (gBH1) could efficiently inhibit plaque formation in primary chicken embryo fibroblast cells (CEFs) with 50% inhibitory concentrations (IC50) of below 12 μM. These peptides were also significantly able to reduce lesion formation on chorioallantoic membranes (CAMs) of infected chicken embryos at a concentratio

SUBMITTER: Wang X 

PROVIDER: S-EPMC3113977 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature