Comparison of three tests of homogeneity of odds ratios in multicenter trials with unequal sample sizes within and among centers.

ABSTRACT:

Background

Mixed effects logistic models have become a popular method for analyzing multicenter clinical trials with binomial data. However, the statistical properties of these models for testing homogeneity of odds ratios under various conditions, such as within-center and among-centers inequality, are still unknown and not yet compared with those of commonly used tests of homogeneity.

Methods

We evaluated the effect of within-center and among-centers inequality on the empirical power and type I error rate of the three homogeneity tests of odds ratios including likelihood ratio (LR) test of a mixed logistic model, DerSimonian-Laird (DL) statistic and Breslow-Day (BD) test by simulation study. Moreover, the impacts of number of centers (K), number of observations in each cen

SUBMITTER: Bagheri Z 

PROVIDER: S-EPMC3114016 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature