Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum.

Objectives

To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality.

Methods

PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study.

Measurements and main results

Serum PARC/CCL-18 levels were higher in subjects with COPD than in smokers or

SUBMITTER: Sin DD 

PROVIDER: S-EPMC3114051 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature