Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury.

ABSTRACT:

Rationale

During acute lung injury (ALI), mechanical ventilation can aggravate inflammation by promoting alveolar distension and cyclic recruitment-derecruitment. As an estimate of the intensity of inflammation, metabolic activity can be measured by positron emission tomography imaging of [(18)F]fluoro-2-deoxy-D-glucose.

Objectives

To assess the relationship between gas volume changes induced by tidal ventilation and pulmonary metabolic activity in patients with ALI.

Methods

In 13 mechanically ventilated patients with ALI and relatively high positive end-expiratory pressure, we performed a positron emission tomography scan of the chest and three computed tomography scans: at mean airway pressure, end-expiration, and end-inspiration. Metabolic activity was measured fro

SUBMITTER: Bellani G 

PROVIDER: S-EPMC3114052 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature