Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm ozone for 6.6 hours.

ABSTRACT:

Rationale

Exposure to ozone causes a decrease in spirometric lung function and an increase in airway inflammation in healthy young adults at concentrations as low as 0.08 ppm, close to the National Ambient Air Quality Standard for ground level ozone.

Objectives

To test whether airway effects occur below the current ozone standard and if they are more pronounced in potentially susceptible individuals, such as those deficient in the antioxidant gene glutathione S-transferase mu 1 (GSTM1).

Methods

Pulmonary function and subjective symptoms were measured in 59 healthy young adults (19-35 yr) immediately before and after exposure to 0.0 (clean air, CA) and 0.06 ppm ozone for 6.6 hours in a chamber while undergoing intermittent moderate exercise. The polymorphonuclear neutr

SUBMITTER: Kim CS 

PROVIDER: S-EPMC3114053 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature