RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.

ABSTRACT:

Rationale

Vascular endothelial growth factor (VEGF) regulates vascular, inflammatory, remodeling, and cell death responses. It plays a critical role in normal pulmonary physiology, and VEGF excess and deficiency have been implicated in the pathogenesis of asthma and chronic obstructive pulmonary disease, respectively. Although viruses are an important cause of chronic obstructive pulmonary disease exacerbations and innate responses play an important role in these exacerbations, the effects of antiviral responses on VEGF homeostasis have not been evaluated.

Objectives

We hypothesized that antiviral innate immunity regulates VEGF tissue responses.

Methods

We compared the effects of transgenic VEGF(165) in mice treated with viral pathogen-associated molecular pattern pol

SUBMITTER: Ma B 

PROVIDER: S-EPMC3114061 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature