Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study.

ABSTRACT:

Objective

To identify the range of glycemic levels associated with the lowest rates of complications and mortality in older diabetic patients.

Research design and methods

We conducted a retrospective cohort study (2004-2008) of 71,092 patients with type 2 diabetes, aged ≥60 years, enrolled in Kaiser Permanente Northern California. We specified Cox proportional hazards models to evaluate the relationships between baseline glycated hemoglobin (A1C) and subsequent outcomes (nonfatal complications [acute metabolic, microvascular, and cardiovascular events] and mortality).

Results

The cohort (aged 71.0 ± 7.4 years [means ± SD]) had a mean A1C of 7.0 ± 1.2%. The risk of any nonfatal complication rose monotonically for levels of A1C >6.0% (e.g., adjusted hazard ratio 1.09 [9

SUBMITTER: Huang ES 

PROVIDER: S-EPMC3114320 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature