Normal fasting plasma glucose and risk of type 2 diabetes.

ABSTRACT:

Objective

To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes.

Research design and methods

Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors.

Results

During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The final model demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL.

Conclusions

Our data suggest that FPG

SUBMITTER: Brambilla P 

PROVIDER: S-EPMC3114342 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature